In the slime rancher world, you can find microbes that cause diseases slimes can randomly get, but can spread from slime to slime. You can raise a slimes cure level, cure its disease or make it temporarily immune to all diseases by using Pills. Here is a list of microbes.

Add your own diseases at the bottom of the page.

Leukslimia (Non-Lethal)


Leukslimia occurs randomly when a largo or tarr is formed or, being infected by microbes, consuming Tarr Plorts, or close contact with one. It does not infect grass slimes.


It will make slimes look like a puddle of tarr. It causes depression to slimes making them only eat their favorite food. They will only produce only one tarr plort which, when consumed, causes Leukslimia or tarrs. You can cure these by splashing them with water to make a random plort. These slimes unlike tarrs, don't expire, but will die instantly when in contact with water and can be cured with a grass plort or pill.

Radiated Disease (Non-Lethal)

This disease makes all affected slimes gain a radiated aura, like the rad slime, rad slimes are immune to this disease. The range and damage of the aura depends on if its a largo or single slime, and what its cure level is. It can do major damage to your slimes even though it's not lethal. This is because rad slimes are immune to the radiation, and other slimes are immune to external radiation, but when the radiation is inside the slime, it's poisonous. It causes a slime to slowly lose the ability to function. After one day it produces one plort when fed it's favorite, and after a week it has gotten to the point where it cannot move because it is in so much pain. It does not go way until fed a water pill.

Boom Disease (Sometimes-Lethal)

The boom disease makes all affected slimes explode randomly with no warning, boom slimes are immune to this disease. The frequency of the explosions and explosion range depends on its cure level, however the range can also depend on if its a largo or not. The reason it can be lethal is because while the body chemistry of a boom slime allows it to safely explode without combusting, other slimes do not have this and so can combust with a big enough explosion. High amounts of internal heat/energy tend to make explosions stronger and therefore more likely to kill. Small slimes with no cure level have a 25% mortality rate, largos have a 50% mortality rate. Crystal slimes and other slimes with a high body heat (like dragon slimes) have double the mortality rate of their respective size and cure level, so do slimes that produce energy (like rad slimes). This disease lasts 3 days, any slime that survives is immune.

Feral Disease (Non-Lethal)

Feral Disease makes all affected slimes become feral, attacking the rancher and forgetting who they are. Even though it is named Feral Disease and it's most known effect is aggressive behavior, there are other effects that are related to forgetting, and this disease is really a contagious form of amnesia. These effects include forgetting what it's diet is (producing no plorts when eating the wrong food) and forgetting where it lives. However, if a slime has been taken good care of, it is immune to the disease, as only stress can make a slime's immune system weak enough to be infected. Cure level does not affect this disease, it has to go away on it's own. This disease is used in many mini games.

Blob Disease (Non-Lethal)

The Blob Disease will make slimes into a 2 dimensional puddle on the ground, refusing to do anything, and only producing 1 plort if its fed its favourite food, producing none if fed anything other. Cure level does not affect this disease, puddle slimes are immune to this disease. It goes away on it's own after three days.

Rock Disease (Lethal)

The Rock Disease will trap slimes in a rocky shell, hurting them over time. Agressive slimes will use their abilities to break out of the shell and keep it from growing enough to suffocate them but docile slimes will end up dying if not fed a cure pill. Cure level increases the time you have before the slime dies, Rock slimes are immune to this disease.

Chomp Disease (Lethal)

Chomp Disease will make a bunch of small microbes start eating at the slime, ending up killing it if not cured with a cure pill. The Cure Level will increase the time before the slime dies. Honey Slimes, Strawberry Slimes, and other food based slimes are killed twice as fast from this disease.

Tarr Disease (Lethal)

Tarr Disease slowly turns slimes into tarrs. Dark Slimes and Angelic Slimes are immune to this disease, and grass slimes are immune to this disease. Here is how it works: getting grabbed by a tarr without being eaten has a very low chance of transmitting the disease, but it has a 50% chance of spreading if bitten by an infected slime. The amount a slime is infected goes up by 1% gradually until it reaches 99%, and it is also the percentage of how much of the slime has turned black. It takes roughly a week for a slime to reach 99%. When a slime is first infected, it is difficult to notice physically, and they behave normally. When the slime reaches 25%, they need to eat a lot more. When they reach 50%, they isolate themselves, and other slimes stay away from them, they are banished from slime holes. They will be less mobile, behaving a bit sluggishly. When they reach 75%, they are very weak, moving slowly. They have strange behavior, always drooling and sleeping when not seeking food. While Tarr no longer eat these slimes, they are prone to starvation. When they reach 90%, they are hostile, attacking any slime they come across, and trying to bite them. This is when they are dangerous, because these guys can spread the disease quite fast in a large population. When they reach 99%, they stop progressing, and mutate into a half-tarr. After a week of that, they finally become a Tarr.

Muscle Disease (Indirectly-Lethal)

This Disease, unlike the rest, are actually helpful to slimes, and increase in chance depending on how much cure they have, it increases their damage dealt, and they produce double plorts. It spreads quickly too! However when you have this with the Feral Disease it can be trouble. Until after a week of this... Then the slime becomes tired really quickly from all the excess energy it's expending, making the slime go comatose and eventually die from starvation or thirst. A green pill will end the disease.

Statues Glare (Lethal)

Microbe onset paralysis, nicknamed Statues Glare as a nod to the gray pigmentation of the membrane as a side effect, is a disease that infects Rock Slimes by turning them to stone. It takes 48 hours for the effects to instantly set in. While dormant, the simple heartbeet test will help decide whether a slime has Statues Glare, if a slime that would normally chomp down a heartbeet refuses it entirely, it has Statues Glare. Statues Glare is incurable, and can be spread via contact. However, 50% of those infected survive, and they are immune to the disease once it goes away.

Parasites (Indirectly Lethal)

While not technically a microbe, parasites are still a very serious disease. Parasites can produce offspring within the slime every day. If the host comes into contact with another slime for 3 seconds, one of the offspring will infect it. Parasites require food, and make a slimes appetite increase. The more parasites within a slime, the hungrier it gets. Without enough food slimes can starve, along with the parasites inside of them. An easy way to tell if a slime has parasites is to throw it into an incinerator, an easy test meant to be done on a single slime from an entire batch of suspected hosts. Parasite infected slimes will clump together, so the parasites can share stories from their lives.

Insanity disease (Unknown if lethal)

Insanity disease is unusual in that it can emerge from any slime at any time, but does not spread very well. Typically, only 4 to 6 slimes will be infected at a time. Within 24 hours of the original slime getting infected, all slimes with this disease will vanish. Currently no footage of the slimes disappearance has been recorded. The most common theory is that the slimes become insane, breaking out of their corrals and escaping in the night to an unknown location. Another theory states a monster in the night seeks out infected slimes and takes them away. Disappearances are often coupled with very silent slimes the next morning, evidence of the slimes having moved all around the ranch, and in very rare cases, malfunctioning corral walls.

Bouncy disease (Non-lethal)

The microbe lines the membrane of the slime, expanding when in contact with surfaces. This causes the natural slime inflammation immune response, which in turn causes bounciness. Slimes will often look like they are having the time of their life, this is due to their face muscles having the exact same inflammation reaction, all the time. Other slimes will intentionally bounce into them to try to catch the disease, only to have obstructed breathing, loss of vision, and a whole lot of tiredness. They might bounce right off into the slime sea, which can be a problem for ranchers.

Frost Disease (Lethal)

This disease can freeze slimes which aren't cold, and worse, can create Frostbites. Despite being cold-related, it is not caused by exposure to cold weather, and it does not matter how hot it is, a slime can still die from it -this disease is an instant death in a blizzard, where outside temperature factors are likely to speed up the freezing process, which would otherwise take roughly 3 and 1/2 days. Temperature decrease is not affected by being in a hole or sheltered place. The temperature value slowly goes down, and is not affected by any outside factors that would normally add warmth or delay/stop coldness. In addition, the slime slowly turns white, and later stages begin covering the slime with frost. Stage one, the slime is a little cold, for no apparent reason, as if the temperature outside was cold. When their body temperature reaches 96 degrees, they have not enough energy to do highly energetic actions -like fighting or bouncing high. At 94 degrees, the slime's extremities are entirely white, so is the surrounding area, and they can hardly move. At 93 degrees, frost forms on a slime's extremities, and existing frostbite happens 25% faster. At 92 degrees, the slime can't move, and frost forms on the slime's body. This is your last chance to cure them. At 91 degrees, the slime freezes solid, and it is too late to treat the slime, as they cannot be thawed and will either die of hypothermia or transform into a Frostbite after a day. This disease is cured by a green pill.

Slime Plague (VERY Lethal!)

This disease is formed when a group of microbes all settle on a single Rad Slime. The Radioactive Aura causes the microbes to become very unstable. Because of this, the microbes quickly expand and duplicate themselves without splitting apart, turning the aura a pulsating black-ish color. Any slimes (except certain Bosses) within this "Death Aura" immediately catch the Plague and get sick. The sick slimes also gain a "Death Aura," but it is invisible to the naked eye. This Death Aura rots food around it, but slimes don't take notice of the fact that what they are eating is rotten. Eventually, the sick slimes will spontaneously erupt into a shower of black goo. Any slimes that touch this "Death Goo" are immediately turned into a "Plague Tarr," lasting for more than a few days, and requiring immense amounts of water to eliminate. There is currently NO antidote for the Slime Plague.

Bite Disease (Lethal?)

This disease is formed when a Pink Slime(canon) or any Fanon Slime gets so hungry, they can even cannabalism! If they eat five other Slimes, it'll turn into a Puffball Slime! If it eats four more Slimes, it'll turn into a Goo Slime!!! If it eats ONE more Slime, it'll become a Goo Tarr and RACE AFTER YOU! But remember, other Tarr first, even Gold Tarr!

Ink Virus (Indirectly Slightly Dangerous)

The Ink Virus is a moderately common disease, that makes slimes able to spit some sort of paint, and splash it on the ground by bouncing. The microbe harmlessly melts parts of the host slime that can regenerate quickly to eat, and the leftovers get turned into ink stuff. Rad Slime's splashes have a small radioactive aura, a Boom Slime's splash can explode like pop-rocks, but on a more harmful scale, and A Rock Slime's splashes has rocky spikes on it. Watch out for those. The Ink Virus spreads quite quickly, and can spread by slime spit/splash or touch, and is hilarious when paired up with the Bouncy disease. Can be cured with a Water Pill, and wears off in 5 in-game days.

Bewitched Disease (Unknown if lethal)

The Bewitched Disease is a rare type of 'disease' that happens when a slime eats a Fae Hen, a rare variation of Hen Hen. If you see one, vac as fast as possible to avoid having a slime eat it, BUT if a slime does eats one, it will only eat Fae Hens! Ranchers have been known to also act strange if they eat a Fae Hen. There is no known cure for the disease, but Tarrs and shimmer slimes seem immune.

Muta Disease (Can be Lethal)

As a mutation disease, the Muta Disease is a disease that has an extremely rare chance to occur when curing a Tarr. A sign of the Muta can be found when curing a Tarr; where only the slime appears and the plorts the Tarr was made from are not there. This is because the slime still contains the plorts within it's body, but due to the cure, is not turning into a Tarr. Later on, the slime will rapidly change colors for an hour in game, yet acting like nothing is happening. At the end of this, the slime will feel a burning sensation as the slime gradually turns into another slime, which is chosen from the plorts and slimes it had eaten as a Tarr, but is more likely to end up as one of the two plorts that turned it into a Tarr in the first place. It is only lethal if the slime turns into an aggressive slime, such as Rock or Boom. This is because slimes with harmful abilities will retain Tarr behavior and eat whatever slime it comes across, and they will do this without sleeping until they drop from exhaustion after 1 day and then go comatose and die.

Derpslimia (Indirectly-Lethal)

Derpslimia is a rare disease that makes slimes dumb, and it is spread by eating chickens with Derpslimia. It does this because it affects the brain. Stage one, the slime is dormant, behavior is normal. After a day of being infected, the slime will fall comatose, yet it will look a bit entranced with a dizzy expression. After another day of this, if it hasn't been eaten, it's behavior depends on it's size. Small slimes will try to be eaten by a Tarr, while largos will intentionally eat a plort to be a tarr. Either way it's face looks derpy, hence the name. While it looks funny, it's not a good sign. The Tarr that results either way is infected. Infected Tarr take longer to die, the gunk they leave sticks around a bit longer, and they ignore chickens. Any chicken that touches it is infected. No chickens display any symptoms, and that's because the only reason the disease infects chickens is for reproduction. Purple pills are perfect for curing this disease. Despite being on the Microbes page, this is actually a microscopic parasite.

Cake Disease (Lethal)

The Cake Disease is a disease exclusive to honey slimes. If a slime is infected by those "Cake Microbes", their heads will ooze sweet syrup and some candles will appear in their heads. Their plorts will have candles too. This is dangerous because the slime will want to be eaten, and all the symptoms attract the attention of Tarr and carnivorous slimes. And if any slime eats an infected slime or plort, they are infected too. The ingredients for the cure pill are: Cuberry, Mint Mango and Pogo Fruit. Put the things in the pill machine and wait eight days. It will produce a rainbow pill, which looks like a cake.

Entranced (Neutral)


When any fruit eating slime like the Phosphor Slime eats a Hypnogranete, their eyes turn a distinctve purple and will move more slowly, and not accept any other foods.This effect is caused by a bacteria exclusive to the Hypnogranete's seed flesh known as Tracnoisificus. This bacteria moves up to the slime's gooey brain and infects it, turning the eyes the signature violet. Humans have eaten this fruit, and have known to either disseapear or smash any other food that is not a Hypnogranete on the ground. Their eyes turn purple, too! Eaters of the fruit also claim to find the Hypnogranete is incredibly, addictively tasty and move sluggishly.

So, moral of the day, DO NOT EAT A HYPNOGRANETE.

Leukotosis (Lethal if not cured within 6 days)

Leukotosis is a very rare disease, and in turn a very dangerous one. Leukotosis is caused by rampant Virosus cells, which are mutated flu cells. Puddle slimes are the only slimes immune to Leukotosis, instead living in harmony with the virosus cells.


Membrane damage

When a slime is infected, virosus cells tear up the slime membrane of the slime, making it very puddly and slushy. Puddle slimes are immune to the first symptom. This also causes the rad slime's aura to flicker at times.

Aura corrosion

The second symptom of Leukotosis is the slow fading of slimes with auras (like the rad slime). When the aura starts fading, it shows signs of scratches and cracks on it. Virosus cells are immune to the aura.

Rammer syndrome

When the Virosus cells breach the aura or membrane, they ride the blood stream to the slime's brain and hijack it. This forces the slime to hit the corral walls. The slime will be very slushy now, so it will splat against the wall. By now, pills will not work and the slime needs to continually eat to fight the infection.


Intense pain on the frontal lobe of a slime's brain causes it to try and consume other slimes. This makes the slime dangerous and able to transmit the disease to other slimes.


Hemato-disruption is caused when Virosus cells, ones that get stuck on the blood vessel wall, eat the walls of the arteries and disrupt the procedure that causes clotting. The now free-floating blood makes the slime turn red and loose energy fast.

Total circulatory system failure

After a day of Hemato-disruption, the slime will stop moving entirely. No oxygen is flowing to the organs, and after 8 minutes of failure, the slime will die. It is possible to save the slime from death.

The Virosus cells have committed suicide due to lack of nutrients, leaving the slime extremely tired. shown by a slow breathing, closed eye puddle.

The only way you can save the slime is by injecting pogofruit juice. The cells of the fruit act like blood cells and close off the wounds. The slime's immune system is fine with the juice, and the slime turns back to normal. After 7 days, the slime has fully recovered and is pumping regular blood through it's systems.

Common Cold (Sometimes-Lethal)

The common cold is a disease which can infect most slimes. It occurs more in winter, but can happen in other seasons too. Slimes are immune to this disease once they have survived it, they cannot get it twice. There are four stages of this illness. Water-based and aquatic slimes are immune to this disease. It is believed that the common cold originates from a strain of the common cold in humans, making it a zoonotic disease.

Stage one: There are no symptoms, the slime is not contagious. Lasts one day.

Stage two: The slime is still not contagious. It begins to behave sluggishly, moving at a slower pace and only leaving their slime hole to eat. Any behavioral quirks like rolling or exploding will not happen, and rad slimes will produce a weak aura. All slimes stop producing plorts. Slimes also get a fever and will start sweating and have visible blushing. This is far from lethal for most slimes, but some slimes can die from it: slimes with a high amount of body heat (like crystal slimes) get a fever that is MUCH worse. They begin frantically doing things like producing crystals and staying in the water if there is any, in an attempt to cool themselves down. These slimes must be cured in this stage or else they will combust into flames and die when they progress to the next stage. This stage lasts one day.

Stage three: Slimes are now contagious. The slime has now lost it's appetite, only eating it's favorite foods. The slime does not enter slime holes at all, as it has been banished by it's peers to avoid spreading the illness. This makes infected slimes vulnerable to predation. The slime just sleeps when not eating or fleeing a predator, and it periodically coughs up yellow mucus. The puddles only last a few seconds, but any slime that touches it or gets coughed on is infected, and any fruit that touches the mucus is rotten. Translucent slimes have a small core of yellow mucus visible. Other slimes will stay away from infected slimes, who will try to isolate themselves. This stage lasts three days, and there is a 50% chance that a slime will skip the next stage and survive.

Stage four: This is when it becomes lethal. Slimes are now coughing near-constantly, and cannot eat. They will have open mouths, as the mucus has surrounded their body cavity and so they cannot breathe through their body. You will need to monitor an infected slime constantly if you do not have the cure, as most slimes in this stage die if they are not cared for. Slimes die by suffocating on the mucus, they will be rapidly breathing and have a wide-open yellow mouth, and blue on the face, they will be coughing huge amounts of mucus in a desperate attempt to survive. You can save a suffocating slime by squirting them with water, and this will not even happen in the first place if they are in the water. The whole process of stage four will repeat until one day has passed.

killing disiease (lethal if not cured within 10 days)

parisites start a paradox of parisite disieases

stage onel the slime is uncounchious parisites start eating the brain theres a 25% chance of living after 1 day

stage two: the slimes is slowly gettng eaten theres a 75% chance of survival after 6

final stage: the slimes organs are slowley rotted by the bugs poop use the grass to save the slimes life dies after 3 days

Slimeisia (Non-Lethal)

Slimeisia is a common disease that only infects slimes. It is essentially the slime version of the common cold, but much less lethal.

Stage 1

The slime is perfectly healthy, however some slimes ignore it.

Stage 2

The slime is sluggish, jumps less, plays with slimes less often, and eats less.

Stage 3

Slimeisia is now contagious. Colder slimes have increased body heat, hotter slimes don't release as much heat, and the slime is much less willing to interact, the slime coughs and sneezes, and they'll carefully (to prevent contagiousness) slide down into their own slime hole to sleep the slimeisia away

Seronin (Non-Lethal)

Seronin occurs when too many microbes clump together in a Slime's body. This causes Slimes to become hyperactive and use up most of their energy in just one hour. Cure this with the Green Pill. It cannot be cured at Stage Four.

Stage One

Infected Slimes use more energy than usual, jumping on ranchers as soon as they come close.

Stage Two

Infected Slimes attempt to get out of Corrals, and are sad to not have much place to move around in.

Stage Three

Infected Slimes repeatedly produce Seronic Plorts, which are seemingly useless Plorts that sell for nothing.

Stage Four (Final Stage)

Infected Slimes cannot be cured anymore, will be able to break out of an Air-net instantly, and if the host is a Dog Slime, cannot be trained.

Disease made by Rare Tabby

Petrisist (Lethal)

Petrisist occurs when too many Seronin microbes gather in a Slime's body. The Slime becomes so hyperactive, they spend all of their energy jumping around and don't use any of it to think, causing them to forget who they are. They end up mutating into a P!nk Slime. Pink Slimes are immune to Petrisist.

Stage One

The Slime begins using all of it's energy for it's bounces. It can be cured, but only with a Seronic Plort that has been affected by a Slime Charm.

Stage Two

The Slimes forgets who it is. It begins to use some of it's energy to break out of Corrals by breaking the energy fields that make up the walls. It can be cured.

Stage Three

The Slime turns pink. It shows strange behaviour that rapidly changes. Now it doesn't know anything, so it won't eat, won't run from Tarrs, and won't eat Plorts. All it does is jump around at extreme speeds. It can be cured.

Stage Four (Final Stage)

It loses all of it's features before, and slowly turns into a P!nk Slime. It can be cured, however, and now spends every single bit of energy moving. It has become blind, and it has become deaf. If cured as a P!nk Slime, it becomes a normal P!nk Slime. Then, it remembers it's past life, and becomes extremely upset.

Disease made by Rare Tabby

Luck disease(For the infected)

This is a rare disease that makes the affected slime a lucky slime but when you feed it, it explodes and bad events happen like there being a chance a drought occurs or another disease, and worse of all, when the slime explodes, it spreads and transmits the disease to other slime. Even the lucky slime can be affected. Some report weird events like firestorms on their ranch.

Big Slime Disease (Non-Lethal)

This disease doesn't really do anything, except for the fact it makes normal slimes as big as Gordos! Largos aren't affected. The big slimes required 5x the food to be satisfied.

Algae Bleach(lethal if not treated)

This disease affects reef and coral slimes, slowing them down, turning them white and eventually causing them to pass on

Vectors(things that can transmit it)

Flish, Barcs(fiish and barcs have red algae covering them), Octo Slimes(when infected, have a permanent black line, can be cured by a newt plort, non lethal to them), reef and coral slimes

Stage 1(oozing)

The Slime's coral begins to turn lighter and the skin(slimy part) becomes slightly more liquid(leaves splats when bouncing at all), if detected, the parasitic algae can be cured by a newt plort,this stage lasts for 5 days

Stage 2(weakening)

The Slime then begins to slow down, with the coral eventually turning white, slowly over the course of 5 days it then looks hungry all the time, very sadly shambling along, rarely bouncing, this stage lasts for 2 days, can be cured by a newt plort

Stage 3(Lethal stage)

The Slime then loses mobility, panics ferociously, rapidly change facial expressions once every 00:10 minutes and the algae begins to grow on its coral, it begins to leak water, this stage can be cured by 3 newt plorts and leaving the slime to dry for 10 ingame minutes near heat(sunlight, incinerator, etc.), otherwise it dies

Slime fungus(very lethal, works quickly)

This fungus is a highly lethal disease that infects amphibious slimes and ones that breathe through their skin like newt slimes, it is spread via water

Stage 1(rash)

The Slime first develops a few small dark patches on its skin, then it becomes slimier, leaving splats when bouncing, similar to algae bleach, this stage lasts for one day, can be cured by using SS light or pills

Stage 2(terrifying weakness)

The Slime then becomes weak and dark, and dies the next day, can still be cured by SS light and pills

Hypno Fungus (lethal over the course of time)

This fungus is a serious disease that infects slimes, mainly insectoid slimes and turns them into mindless zombies that seek out high places near food sources like veggie fields or fruit trees also fungal slimes are immune

Stage 1("Pixie" dust)

The slime begins to shower "dust" as it hops along, it appears a glowing blue when hit by a pulse wave and the slime may have small "holes" in it's wings/exoskeleton, can occur in other slimes, can be cured by SS light and a grass plort

Stage 2(Mild hypnosis)

The "holes" and pixie dust disappear the next day, but the slime will begin to eat less and become hungry, still the same cure as before, also if you leave and quickly come back, you may see the slime having swirly eyes,most slimes stop at this stage and recover, but insectoid slimes progress to stage 3, similar cure

Stage 3(Full control, highly infectious and lethal)

The slime will now flash between swirly eyes and normal, now completely refuse food and begin randomly flapping its wings faster than normal, but not flying(if it has them), at about 17:30 at night, they will fly or go to a high and shady place and cling on, dying in the process upon clinging or if one is not found, dies at 20:00 , several thin mushroom stalks then sprout from the dead slimes back and head and release glowing blue spores, which can infect other slimes, this stage still has a similar cure, and the body can be removed by first blasting it with a trickster plort off the surface(trickster slimes will also blast them off and throw them away), then vaccing and throwing the body into the slime sea/incinerator

SPECIAL: If 50 stage 3 infected slimes(anywhere on the ranch) are infected at once, they release all the fungus in them and it travels to the pink gordo island and... (link to a page)


Gallery is a kinda rare disease, that makes pages show series of pictures on their bottom.